![]() ![]() Recent percutaneous coronary intervention (PCI) (Those with the following characteristics were excluded from the study: Patients were enrolled if they presented 12-48 hours following chest pain onset. Is associated with a reduction of infarct size in patients with AMI presenting > 12 hours after symptom onset.ĪMI was defined as chest pain lasting ≥ 20 minutes and ST-segment elevation or new pathological Q-waves. The Beyond 12 Hours Reperfusion Alternative Evaluation (BRAVE-2) trial was designed to assess whether an invasive strategy The value of an acute invasive treatment in these patients. Although availableĬlinical evidence discourages the use of thrombolytic therapy in this setting, no randomized trials have actually assessed Therefore, current guidelines do not recommend reperfusion treatment in these patients. Previous trials with thrombolytic agents have shown little or no benefit of attempting coronary reperfusion within Presenter: Adnan Kastrati, MD, Deutsches Herzzentrum (Munich, Germany)Ī large proportion of acute myocardial infarction (AMI) patients present to the emergency room > 12 hours after the initiation ![]()
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